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Depression, a pervasive mental health issue, often leads people into a relentless cycle of medication adjustments without addressing underlying causes.  

The prevalent use of antidepressants, although beneficial for some, has drawn criticism due to side effects and the inability to address root causes, such as nutritional deficiencies or hormonal imbalances. 

SSRI antidepressants can increase serotonin activity, but only temporarily. And this comes at a cost. Common side effects include nausea, insomnia and sexual dysfunction, among others.  

Despite these drawbacks, the medications are not designed to correct fundamental biochemical imbalances, which are often the precursors to mood disorders.  

These meds don’t provide any minerals or vitamins, which are required to make serotonin and norepinephrine — two key neurotransmitters involved in producing “happiness” and mood stability.  

Serotonin is predominantly made in the gut, not your brain. Foods rich in tryptophan — such as dates, papaya and bananas — can naturally enhance serotonin levels, potentially reducing depression symptoms. 

On the supplement front, several nutrients play crucial roles in neurotransmitter synthesis: 

1. Vitamin C is essential for the metabolic pathways that produce serotonin and other neurotransmitters.
2. Vitamin B1 (Thiamine) influences the release of serotonin and norepinephrine, impacting mood and energy levels.
3. The active form of folic acid called 5-MTHF facilitates the production of mood-regulating neurotransmitters. The prescription drug called Deplin is made of this B vitamin. 
4. Magnesium plays a multifaceted role in mental health, affecting serotonin regulation and helping prevent migraines, a common comorbidity with depression.
5. Nutrients that support the thyroid, such as tyrosine and iodine, are essential for the production of thyroid hormones. Additionally, mood instability is commonly associated with hypothyroidism.
6. Eleutherococcus senticosus (Siberian ginseng) is an adaptogenic herb that supports adrenal health and helps the body cope with stress, enhancing overall well-being.

Seek a holistic strategy 

While it’s tempting to seek a simple solution through medication or natural remedies alone, the most effective approach to managing depression involves a comprehensive strategy that addresses dietary, biological and psychological factors.  

It’s crucial to consult with healthcare professionals to tailor treatment, whether through dietary adjustments, supplements or conventional medications. 

The conversation around depression treatment is evolving, emphasizing the need for a holistic approach that respects both the complexity of the human body and the individual experiences of those affected by mood disorders.  

Millions of people are searching for alternatives that tackle the root causes of depression beyond just managing symptoms. And you will probably agree that mental health concerns have become more prevalent in the post-pandemic season…not to mention the constant social media ‘irritations’ that never let our brain shut off. 

This shift towards a more integrative perspective broadens treatment options and aligns more closely with the body’s natural processes. I’m a big believer in holistic approaches and nourishing the body’s metabolic pathways. 

Does this topic interest you? I have a more comprehensive version of this article with additional treatment options. To have it emailed, please sign up for my free weekly newsletter at suzycohen.com. 

This information is opinion only. It is not intended to treat, cure or diagnose your condition. Consult with your doctor before using any new drug or supplement. 

Suzy Cohen is a registered pharmacist and author of The 24-Hour Pharmacist and Real Solutions from Head to Toe.