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Dear Mayo Clinic: I thought I had an ulcer, but my doctor ruled that out and wants to run tests. He said it could be functional dyspepsia. What causes this, and is it treatable?

A: Functional dyspepsia (also called nonulcer dyspepsia) and peptic ulcers can feel much the same.

But unlike a peptic ulcer, which involves open sores in the digestive tract, functional dyspepsia involves recurring indigestion or stomach pain that has no obvious cause.

Common signs and symptoms of functional dyspepsia include a burning sensation or discomfort in your upper abdomen or lower chest, bloating, belching, an early feeling of fullness when eating and nausea. While not life-threatening, the symptoms can significantly affect your quality of life.

Use of endoscopy

One component to help with diagnosis is endoscopy, in which a thin, flexible, lighted instrument (endoscope) is passed down your throat so that your doctor can view your esophagus, stomach and the first part of your small intestine.

Endoscopy also allows your doctor to collect small pieces of tissue (biopsy) from your stomach or duodenum to look for inflammation or cancerous growths.

Your healthcare provider can determine whether an endoscopy is needed, but endoscopy generally is recommended in adults 60 and older who have symptoms. A normal result on this test most often indicates functional dyspepsia.

Endoscopy also may be performed on adults younger than 60 who have “alarm” features — such as weight loss, anemia, difficulty swallowing or persistent vomiting — along with dyspepsia symptoms.

If no abnormal results are found with endoscopy, a noninvasive breath or stool test to check for the Helicobacter pylori (H. pylori) bacterial infection may follow to guide the course of treatment.

This test also is used for adults under 60 with no alarm features. If H. pylori is present, your healthcare provider may recommend an antibiotic to eliminate the infection.

Ways to reduce stomach acid

For those who test negative for the bacterium, as well as for those whose symptoms persist after antibiotic treatment and clearance of H. pylori, the first line of treatment is to reduce stomach acid.

This may be performed using two types of medications: proton pump inhibitors or H2-receptor blockers.

Proton pump inhibitors reduce acid by shutting down the tiny pumps within stomach cells. Examples include esomeprazole (Nexium), lansoprazole (Prevacid) and omeprazole (Prilosec).

H2-receptor blockers, including famotidine (Pepcid) and ranitidine (Zantac), reduce acid production by blocking histamine receptors in stomach cells.

Cognitive behavioral therapy also may be recommended as a way to cope with the symptoms and reduce the stress that may trigger stomach pain.

Because functional dyspepsia lacks a fully understood cause and its symptoms overlap with other gastrointestinal conditions, the diagnosis of functional dyspepsia can be challenging. Researchers continue to explore better means of clearly identifying it.

Email a question to MayoClinicQ&A@mayo.edu. For more information, visit mayoclinic.org.

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